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Pan, Tao

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overview	Our research focuses on (i) functional genomics and biology of tRNA including microbiomes and (ii) epitranscriptomics including microbiome-host interactions. tRNA biology: Translational regulation relies on the dynamic properties of tRNA that constantly change to facilitate response and adaptation to new environments and to control gene expression. We developed high throughput sequencing technologies that measure tRNA abundance, charging and modifications in one single sequencing library. We are investigating the roles of tRNA in translational control and extra-translational functions in mammalian cells. Microbiome: We also developed tRNA-seq as another approach for microbiome characterization. Standard microbiome characterizations include 16S-seq or shotgun metagenomics. Although powerful, these DNA-based methods do not directly report the microbiome activity such as dynamic gene expression which requires the studies of RNA in the microbiome. Our microbiome tRNA-seq results show extensive variations of tRNA abundance and modification patterns in microbiomes from different sources. We also show that tRNA modification dynamics in the microbiome correlates with tuning the expression of specific microbial proteins, indicating that tRNA-seq can provide new insights in microbiome biology. We are further developing this approach to explore the potentials of tRNA-seq to study microbiomes from humans and from the oceans. Epitranscriptomics: Over 100 types of post-transcriptional RNA modifications have been identified in thousands of sites in the transcriptome. They include methylation of bases and the ribose backbone, rotation and reduction of uridine, base deamination, addition of ring structures and carbohydrate moieties, and so on. mRNA modifications are involved in cell differentiation, proliferation, and many other cellular functions and human diseases. Some mRNA modifications can also be removed by cellular enzymes, resulting in the dynamic regulation of their functions. We are investigating the function and mechanisms of mRNA modifications such as N6-methyladenosine (m6A) in the regulation of gene expression. For example, we discovered that m6A modification can alter the local mRNA structure to regulate binding of mRNA binding proteins transcriptome-wide (m6A switch), resulting in changes in mRNA abundance and alternative splicing. Microbiome-host interactions through epitranscriptomics: We are working on elucidating the function of mammalian host mRNA and tRNA modifications in response to the gut microbiome. We found that microbiome reprograms the host m6A modifications transcriptome-wide in a tissue-dependent manner, suggesting that this dynamic epitranscriptomic mark is used in yet unknown ways in microbiome response. We also found that a microbiome dependent, host tRNA modification alters the cellular small RNA pool, suggesting yet another pathway of microbiome response through RNA modifications.
preferred title	Professor

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Value

overview

Our research focuses on (i) functional genomics and biology of tRNA including microbiomes and (ii) epitranscriptomics including microbiome-host interactions. tRNA biology: Translational regulation relies on the dynamic properties of tRNA that constantly change to facilitate response and adaptation to new environments and to control gene expression. We developed high throughput sequencing technologies that measure tRNA abundance, charging and modifications in one single sequencing library. We are investigating the roles of tRNA in translational control and extra-translational functions in mammalian cells. Microbiome: We also developed tRNA-seq as another approach for microbiome characterization. Standard microbiome characterizations include 16S-seq or shotgun metagenomics. Although powerful, these DNA-based methods do not directly report the microbiome activity such as dynamic gene expression which requires the studies of RNA in the microbiome. Our microbiome tRNA-seq results show extensive variations of tRNA abundance and modification patterns in microbiomes from different sources. We also show that tRNA modification dynamics in the microbiome correlates with tuning the expression of specific microbial proteins, indicating that tRNA-seq can provide new insights in microbiome biology. We are further developing this approach to explore the potentials of tRNA-seq to study microbiomes from humans and from the oceans. Epitranscriptomics: Over 100 types of post-transcriptional RNA modifications have been identified in thousands of sites in the transcriptome. They include methylation of bases and the ribose backbone, rotation and reduction of uridine, base deamination, addition of ring structures and carbohydrate moieties, and so on. mRNA modifications are involved in cell differentiation, proliferation, and many other cellular functions and human diseases. Some mRNA modifications can also be removed by cellular enzymes, resulting in the dynamic regulation of their functions. We are investigating the function and mechanisms of mRNA modifications such as N6-methyladenosine (m6A) in the regulation of gene expression. For example, we discovered that m6A modification can alter the local mRNA structure to regulate binding of mRNA binding proteins transcriptome-wide (m6A switch), resulting in changes in mRNA abundance and alternative splicing. Microbiome-host interactions through epitranscriptomics: We are working on elucidating the function of mammalian host mRNA and tRNA modifications in response to the gut microbiome. We found that microbiome reprograms the host m6A modifications transcriptome-wide in a tissue-dependent manner, suggesting that this dynamic epitranscriptomic mark is used in yet unknown ways in microbiome response. We also found that a microbiome dependent, host tRNA modification alters the cellular small RNA pool, suggesting yet another pathway of microbiome response through RNA modifications.

preferred title

Professor

One or more keywords matched the following items that are connected to Pan, Tao

Item Type	Name
Concept	Amino Acid Sequence
Concept	Amino Acyl-tRNA Synthetases
Concept	Antineoplastic Combined Chemotherapy Protocols
Concept	Circular Dichroism
Concept	Computer Simulation
Concept	Geobacillus stearothermophilus
Concept	Base Sequence
Concept	Bacterial Outer Membrane Proteins
Concept	Bacillus subtilis
Concept	Bacterial Proteins
Concept	Binding Sites
Concept	Drainage
Concept	Emergency Service, Hospital
Concept	Emergency Treatment
Concept	Carcinoma, Non-Small-Cell Lung
Concept	Evaluation Studies as Topic
Concept	Chromatography, Gel
Concept	Fungal Proteins
Concept	Chromatography, Thin Layer
Concept	Citrate (si)-Synthase
Concept	Hearing Loss, Sensorineural
Concept	DNA-Binding Proteins
Concept	Drug Synergism
Concept	Digestive System Neoplasms
Concept	Electrophoresis, Polyacrylamide Gel
Concept	Evoked Potentials, Auditory
Concept	Genetic Code
Concept	Hydro-Lyases
Concept	Models, Structural
Concept	Muscle, Smooth
Concept	Genes, Viral
Concept	Genetic Techniques
Concept	Genes, Bacterial
Concept	Feasibility Studies
Concept	Oceans and Seas
Concept	Oncogenes
Concept	Hypertonic Solutions
Concept	Immunotherapy
Concept	Enzyme-Linked Immunosorbent Assay
Concept	Fluorometry
Concept	RNA Ligase (ATP)
Concept	Protein Denaturation
Concept	Molecular Sequence Data
Concept	Laparoscopy
Concept	Nucleic Acid Conformation
Concept	Selection, Genetic
Concept	Speech Intelligibility
Concept	Stress, Physiological
Concept	Protein Binding
Concept	Protein Conformation
Concept	Protein Processing, Post-Translational
Concept	Protease Inhibitors
Concept	Protein Synthesis Inhibitors
Concept	Proteins
Concept	Gastrectomy
Concept	Gastroscopy
Concept	Replantation
Concept	Sequence Homology, Nucleic Acid
Concept	Intestine, Small
Concept	Siloxanes
Concept	Solutions
Concept	Species Specificity
Concept	RNA Probes
Concept	Regulatory Sequences, Nucleic Acid
Concept	Reoperation
Concept	RNA Splicing
Concept	RNA, Transfer, Ser
Concept	Sodium
Concept	Speech Perception
Concept	RNA Processing, Post-Transcriptional
Concept	Sensitivity and Specificity
Concept	Suppuration
Concept	Technetium Tc 99m Sulfur Colloid
Concept	Sulfites
Concept	Styrenes
Concept	Protein Biosynthesis
Concept	Sulfur Radioisotopes
Concept	Stomach
Concept	Genome
Concept	Gene Library
Concept	Randomized Controlled Trials as Topic
Concept	Risk Assessment
Concept	PrPSc Proteins
Concept	Endosonography
Concept	Reverse Transcriptase Polymerase Chain Reaction
Concept	Cryoelectron Microscopy
Concept	Protein Subunits
Concept	RNA Splice Sites
Concept	Electrophoretic Mobility Shift Assay
Concept	HIV Protease
Concept	Stents
Concept	Genome, Viral
Concept	DNA Probes
Concept	Least-Squares Analysis
Concept	Synchrotrons
Concept	Mutagenesis, Site-Directed
Concept	Sequence Alignment
Concept	Spliceosomes
Concept	Alternative Splicing
Concept	Sequence Analysis, DNA
Concept	Protein Structure, Tertiary
Concept	Genes, Reporter
Concept	Consensus Sequence
Concept	RNA-Binding Proteins
Concept	Titrimetry
Concept	Crystallography, X-Ray
Concept	Ultrasonography, Interventional
Concept	Cell Proliferation
Concept	Genome, Insect
Concept	Oxidative Stress
Concept	Muscle, Skeletal
Concept	Protein Splicing
Concept	DNA-Activated Protein Kinase
Concept	Protein Transport
Concept	Cochlear Implantation
Concept	Ossicular Replacement
Concept	Ossicular Prosthesis
Concept	Reactive Oxygen Species
Concept	Protein Folding
Concept	GC Rich Sequence
Concept	Mitochondrial Proteins
Concept	Endoplasmic Reticulum Stress
Concept	Primary Cell Culture
Concept	Green Fluorescent Proteins
Concept	Proteomics
Concept	Microarray Analysis
Concept	Amino Acid Substitution
Concept	DNA Footprinting
Concept	Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept	Oligonucleotide Array Sequence Analysis
Concept	Stem Cell Factor
Concept	Sentinel Lymph Node Biopsy
Concept	Amino Acid Transport Systems
Concept	Catalytic Domain
Concept	Gene Expression Profiling
Concept	Saccharomyces cerevisiae Proteins
Concept	Prognosis
Concept	Databases, Protein
Concept	Promoter Regions, Genetic
Concept	Recombinant Proteins
Concept	Radionuclide Imaging
Concept	RNA, Transfer, Amino Acid-Specific
Concept	Saccharomyces cerevisiae
Concept	Scattering, Radiation
Concept	Sodium Chloride
Concept	Spectrometry, Fluorescence
Concept	Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept	Stomach Neoplasms
Concept	Structure-Activity Relationship
Concept	Sulfur
Concept	Biomedical Research
Concept	Inverted Repeat Sequences
Concept	Static Electricity
Concept	TOR Serine-Threonine Kinases
Concept	High-Throughput Nucleotide Sequencing
Concept	Real-Time Polymerase Chain Reaction
Concept	Culture Techniques
Concept	Immunoprecipitation
Concept	Tympanoplasty
Concept	Spectrophotometry, Ultraviolet
Concept	Spleen
Concept	Staphylococcus aureus
Concept	Substrate Specificity
Concept	Insulin-Secreting Cells
Concept	Immunoblotting
Concept	Models, Statistical
Concept	Evoked Potentials, Auditory, Brain Stem
Concept	Open Reading Frames
Concept	Genome, Fungal
Concept	Transfection
Concept	Viral Proteins
Concept	Blotting, Northern
Concept	Electrophoresis, Gel, Two-Dimensional
Concept	Molecular Structure
Concept	Genome, Human
Concept	Survival Rate
Concept	Argonaute Proteins
Concept	Polymerase Chain Reaction
Concept	Proto-Oncogene Proteins p21(ras)
Concept	Spectroscopy, Near-Infrared
Concept	Scattering, Small Angle
Concept	Neoadjuvant Therapy
Concept	Xenograft Model Antitumor Assays
Concept	Gene Knockdown Techniques
Concept	Molecular Motor Proteins
Concept	RNA 3' End Processing
Concept	Transcriptome
Concept	Escherichia coli Proteins
Concept	Genome-Wide Association Study
Concept	CLOCK Proteins
Concept	RNA, Small Interfering
Concept	Ribosomal Protein S6 Kinases, 70-kDa
Concept	Deuterium Exchange Measurement
Concept	Protein Interaction Maps
Concept	Intracellular Signaling Peptides and Proteins
Concept	Genes, Neoplasm
Concept	Protein Phosphatase 2
Concept	Synthetic Biology
Concept	Cell Survival
Concept	Cloning, Molecular
Concept	Diagnosis, Differential
Concept	Drug Screening Assays, Antitumor
Concept	Enzyme Stability
Concept	Follow-Up Studies
Concept	Laparotomy
Concept	Luminescent Proteins
Concept	Lymphocyte Activation
Concept	Nuclear Proteins
Concept	Organ Specificity
Concept	Prospective Studies
Concept	Protons
Concept	Recombinant Fusion Proteins
Concept	Retrospective Studies
Concept	RNA, Small Nuclear
Concept	Speech
Concept	Staining and Labeling
Concept	Digestive System Surgical Procedures
Concept	Signal Transduction
Concept	Discriminant Analysis
Concept	RNA, Protozoan
Concept	Conserved Sequence
Concept	MERRF Syndrome
Concept	Sequence Analysis, RNA
Concept	Regulon
Concept	PrPC Proteins
Concept	Heat-Shock Response
Concept	Directed Molecular Evolution
Concept	Archaeal Proteins
Concept	RNA Stability
Concept	Membrane Transport Proteins
Concept	Fluorescence Resonance Energy Transfer
Concept	Macromolecular Substances
Concept	Protein Kinase Inhibitors
Concept	Apoptotic Protease-Activating Factor 1
Concept	Molecular Dynamics Simulation
Concept	Nucleotide Motifs
Academic Article	Probing of tertiary interactions in RNA: 2'-hydroxyl-base contacts between the RNase P RNA and pre-tRNA.
Academic Article	Domain structure of the ribozyme from eubacterial ribonuclease P.
Academic Article	Multiple substrate binding sites in the ribozyme from Bacillus subtilis RNase P.
Academic Article	Novel and variant ribozymes obtained through in vitro selection.
Academic Article	Applicability of urea in the thermodynamic analysis of secondary and tertiary RNA folding.
Academic Article	Recognition of the T stem-loop of a pre-tRNA substrate by the ribozyme from Bacillus subtilis ribonuclease P.
Academic Article	The cleavage step of ribonuclease P catalysis is determined by ribozyme-substrate interactions both distal and proximal to the cleavage site.
Academic Article	Altering the intermediate in the equilibrium folding of unmodified yeast tRNAPhe with monovalent and divalent cations.
Academic Article	Modular construction for function of a ribonucleoprotein enzyme: the catalytic domain of Bacillus subtilis RNase P complexed with B. subtilis RNase P protein.
Academic Article	Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme.
Academic Article	Probing RNA structure and function, by circular permutation.
Academic Article	Mg2+-dependent folding of a large ribozyme without kinetic traps.
Academic Article	Mg2+-dependent compaction and folding of yeast tRNAPhe and the catalytic domain of the B. subtilis RNase P RNA determined by small-angle X-ray scattering.
Academic Article	Intermediates and kinetic traps in the folding of a large ribozyme revealed by circular dichroism and UV absorbance spectroscopies and catalytic activity.
Academic Article	Recognition of the 5' leader and the acceptor stem of a pre-tRNA substrate by the ribozyme from Bacillus subtilis RNase P.
Academic Article	Pathway modulation, circular permutation and rapid RNA folding under kinetic control.
Academic Article	Interaction of structural modules in substrate binding by the ribozyme from Bacillus subtilis RNase P.
Academic Article	Folding of a large ribozyme during transcription and the effect of the elongation factor NusA.
Academic Article	Design and isolation of ribozyme-substrate pairs using RNase P-based ribozymes containing altered substrate binding sites.
Academic Article	A thermodynamic framework and cooperativity in the tertiary folding of a Mg2+-dependent ribozyme.
Academic Article	The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits.
Academic Article	Modular construction of a tertiary RNA structure: the specificity domain of the Bacillus subtilis RNase P RNA.
Academic Article	Dimeric and monomeric Bacillus subtilis RNase P holoenzyme in the absence and presence of pre-tRNA substrates.
Academic Article	Single-molecule studies highlight conformational heterogeneity in the early folding steps of a large ribozyme.
Academic Article	The thermodynamic origin of the stability of a thermophilic ribozyme.
Academic Article	Interaction of the Bacillus subtilis RNase P with the 30S ribosomal subunit.
Academic Article	Exploring the regulation of tRNA distribution on the genomic scale.
Academic Article	Getting hotter with RNA.
Academic Article	Efficient fluorescence labeling of a large RNA through oligonucleotide hybridization.
Academic Article	Crystal structure of the specificity domain of ribonuclease P.
Academic Article	Mechanistic insights on the folding of a large ribozyme during transcription.
Academic Article	Real-time RNA profiling within a single bacterium.
Academic Article	Crystal structure of the RNA component of bacterial ribonuclease P.
Academic Article	RNA folding: models and perspectives.
Academic Article	Structure of ribonuclease P--a universal ribozyme.
Academic Article	RNA folding during transcription.
Academic Article	Basis for structural diversity in homologous RNAs.
Academic Article	A systematic, ligation-based approach to study RNA modifications.
Academic Article	Folding of a universal ribozyme: the ribonuclease P RNA.
Academic Article	A large collapsed-state RNA can exhibit simple exponential single-molecule dynamics.
Academic Article	Identification of recognition residues for ligation-based detection and quantitation of pseudouridine and N6-methyladenosine.
Academic Article	Reduced contact order and RNA folding rates.
Academic Article	Single-molecule nonequilibrium periodic Mg2+-concentration jump experiments reveal details of the early folding pathways of a large RNA.
Academic Article	High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma.
Academic Article	tRNA over-expression in breast cancer and functional consequences.
Academic Article	Efficient chemical synthesis of AppDNA by adenylation of immobilized DNA-5'-monophosphate.
Academic Article	Innate immune and chemically triggered oxidative stress modifies translational fidelity.
Academic Article	Profiling non-lysyl tRNAs in HIV-1.
Academic Article	Functional analysis of human tRNA isodecoders.
Academic Article	Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs.
Academic Article	Extended structures in RNA folding intermediates are due to nonnative interactions rather than electrostatic repulsion.
Academic Article	The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.
Academic Article	Tissue-specific differences in human transfer RNA expression.
Academic Article	Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA.
Academic Article	Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA.
Academic Article	Folding of noncoding RNAs during transcription facilitated by pausing-induced nonnative structures.
Academic Article	Discrete structure of an RNA folding intermediate revealed by cryo-electron microscopy.
Academic Article	Selective charging of tRNA isoacceptors induced by amino-acid starvation.
Academic Article	tRNA: Vast reservoir of RNA molecules with unexpected regulatory function.
Academic Article	Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors.
Academic Article	Transcriptional pausing coordinates folding of the aptamer domain and the expression platform of a riboswitch.
Academic Article	Misacylation of tRNA with methionine in Saccharomyces cerevisiae.
Academic Article	Cellular dynamics of RNA modification.
Academic Article	Structure of a folding intermediate reveals the interplay between core and peripheral elements in RNA folding.
Academic Article	An evolutionarily conserved mechanism for controlling the efficiency of protein translation.
Academic Article	Structural basis for altering the stability of homologous RNAs from a mesophilic and a thermophilic bacterium.
Academic Article	Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I.
Academic Article	Selection of circularly permuted ribozymes from Bacillus subtilis RNAse P by substrate binding.
Academic Article	Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11.
Academic Article	Probing RNA structure by lead cleavage.
Academic Article	Higher order folding and domain analysis of the ribozyme from Bacillus subtilis ribonuclease P.
Academic Article	Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p.
Academic Article	Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast.
Academic Article	Genome-wide analysis of aminoacylation (charging) levels of tRNA using microarrays.
Academic Article	Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae.
Academic Article	RNA folding during transcription: protocols and studies.
Academic Article	Misacylation of specific nonmethionyl tRNAs by a bacterial methionyl-tRNA synthetase.
Academic Article	N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Academic Article	Rationalization and prediction of selective decoding of pseudouridine-modified nonsense and sense codons.
Academic Article	A role for tRNA modifications in genome structure and codon usage.
Academic Article	Anti-tumor effects of an engineered "killer" transfer RNA.
Academic Article	Novel RNA substrates for the ribozyme from Bacillus subtilis ribonuclease P identified by in vitro selection.
Academic Article	The 3' substrate determinants for the catalytic efficiency of the Bacillus subtilis RNase P holoenzyme suggest autolytic processing of the RNase P RNA in vivo.
Academic Article	The rate-limiting step in the folding of a large ribozyme without kinetic traps.
Academic Article	Stepwise conversion of a mesophilic to a thermophilic ribozyme.
Academic Article	Diversity of tRNA genes in eukaryotes.
Academic Article	Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation.
Academic Article	Environmental perturbations lift the degeneracy of the genetic code to regulate protein levels in bacteria.
Academic Article	A self-defeating anabolic program leads to ß-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.
Academic Article	N6-methyl-adenosine modification in messenger and long non-coding RNA.
Academic Article	Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription.
Academic Article	Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress.
Academic Article	Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells.
Academic Article	Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface.
Academic Article	N6-methyladenosine-dependent regulation of messenger RNA stability.
Academic Article	Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress.
Academic Article	N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.
Academic Article	High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing.
Academic Article	Adaptive translation as a mechanism of stress response and adaptation.
Academic Article	Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA.
Academic Article	Diversity of human tRNA genes from the 1000-genomes project.
Academic Article	Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress.
Academic Article	RNA epigenetics.
Academic Article	A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus.
Academic Article	Probing RNA Modification Status at Single-Nucleotide Resolution in Total RNA.
Academic Article	Efficient and quantitative high-throughput tRNA sequencing.
Academic Article	Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress.
Academic Article	Probing N6-methyladenosine (m6A) RNA Modification in Total RNA with SCARLET.
Academic Article	Methionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities.
Academic Article	Temperature dependent mistranslation in a hyperthermophile adapts proteins to lower temperatures.
Academic Article	N(6)-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding.
Academic Article	A dual fluorescent reporter for the investigation of methionine mistranslation in live cells.
Academic Article	The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
Academic Article	Correction: Methionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities.
Academic Article	RNA modifications: what have we learned and where are we headed?
Academic Article	N6-methyladenosine–encoded epitranscriptomics.
Academic Article	Interaction of tRNA with MEK2 in pancreatic cancer cells.
Academic Article	Stress Response and Adaptation Mediated by Amino Acid Misincorporation during Protein Synthesis.
Academic Article	Structures of the m(6)A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles.
Academic Article	Determining the fidelity of tRNA aminoacylation via microarrays.
Academic Article	ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Academic Article	Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.
Academic Article	tRNA base methylation identification and quantification via high-throughput sequencing.
Academic Article	Codon optimality controls differential mRNA translation during amino acid starvation.
Academic Article	Function and origin of mistranslation in distinct cellular contexts.
Academic Article	tRNA Misacylation with Methionine in the Mouse Gut Microbiome in Situ.
Academic Article	RNA modifications and structures cooperate to guide RNA-protein interactions.
Academic Article	Global tRNA misacylation induced by anaerobiosis and antibiotic exposure broadly increases stress resistance in Escherichia coli.
Academic Article	N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.
Academic Article	Hili Inhibits HIV Replication in Activated T Cells.
Academic Article	Selective Enzymatic Demethylation of N2 ,N2 -Dimethylguanosine in RNA and Its Application in High-Throughput tRNA Sequencing.
Academic Article	Determination of tRNA aminoacylation levels by high-throughput sequencing.
Academic Article	Dynamic RNA Modifications in Gene Expression Regulation.
Award or Honor Receipt	American Cancer Society, Junior Faculty Research Award
Award or Honor Receipt	American Association for the Advancement of Science (AAAS) Fellow
Academic Article	Identification of N6-methyladenosine reader proteins.
Academic Article	RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis.
Academic Article	Modifications and functional genomics of human transfer RNA.
Academic Article	Pseudouridines have context-dependent mutation and stop rates in high-throughput sequencing.
Academic Article	Queuosine modification protects cognate tRNAs against ribonuclease cleavage.
Academic Article	N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.
Academic Article	Lymphatic mapping and sentinel node biopsy in gastric cancer.
Academic Article	A study of the lengthening and contractility of the surgical margins in digestive tract cancer.
Academic Article	Different criteria for radioactive sentinel lymph nodes has different impact on sentinel node biopsy in breast cancer patients.
Academic Article	[The extensibility and retractility of surgical margins in digestive tract cancer].
Academic Article	Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis.
Academic Article	Sensitive and quantitative probing of pseudouridine modification in mRNA and long noncoding RNA.
Academic Article	Methods for Identification of Protein-RNA Interaction.
Academic Article	Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG.
Academic Article	CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Academic Article	A dual function PUS enzyme.
Academic Article	HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle.
Academic Article	Meta-analysis of randomized controlled trials on laparoscopic gastrectomy vs. open gastrectomy for distal gastric cancer.
Academic Article	An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates.
Academic Article	Biochemical fingerprints of prion infection: accumulations of aberrant full-length and N-terminally truncated PrP species are common features in mouse prion disease.
Academic Article	5-Methylcytosine RNA Modifications Promote Retrovirus Replication in an ALYREF Reader Protein-Dependent Manner.
Academic Article	Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation.
Academic Article	A high-throughput screening method for evolving a demethylase enzyme with improved and new functionalities.
Academic Article	Quantification of Queuosine Modification Levels in tRNA from Human Cells Using APB Gel and Northern Blot.
Academic Article	CMT2N-causing aminoacylation domain mutants enable Nrp1 interaction with AlaRS.
Academic Article	Tissue-specific reprogramming of host tRNA transcriptome by the microbiome.
Academic Article	Pseudouridine RNA modification detection and quantification by RT-PCR.
Academic Article	ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
Academic Article	Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC.
Academic Article	Discovery of novel 9H-purin derivatives as dual inhibitors of HDAC1 and CDK2.
Academic Article	A novel peroxymonosulfate (PMS)-enhanced iron coagulation process for simultaneous removal of trace organic pollutants in water.
Academic Article	Ceftriaxone-induced immune hemolytic anemia in a case with large vestibular aqueduct syndrome after cochlear implant.
Academic Article	Management of magnetic foreign body ingestion in children.
Academic Article	[Clinical analysis of 21 cases of cholesteatoma recidivism after canal-wall-up mastoidectomy with tympanoplasty].
Academic Article	[Electrophysiological characteristics of EABR and its value assessment of cochlear implant].
Academic Article	[Effects of neoadjuvant chemotherapy on the prognostic mortality risk of invasive transitional bladder cancer: a meta-analysis].
Academic Article	Oxidation of tetrabromobisphenol A (TBBPA) by peroxymonosulfate: The role of in-situ formed HOBr.
Academic Article	Multifaceted behavior of Meckel's diverticulum in children.
Academic Article	The Relationship Between EABR and Auditory Performance and Speech Intelligibility Outcomes in Pediatric Cochlear Implant Recipients.
Academic Article	Mitochondrial genome of Protobothrops dabieshanensis (Squamata: Viperidae: Crotalinae).
Academic Article	Long noncoding RNA LINC00511 promotes cell growth and invasion in triple-negative breast cancer by interacting with Snail.
Academic Article	Circadian regulation of apolipoprotein gene expression affects testosterone production in mouse testis.
Academic Article	Quantitative probing of glycosylated queuosine modifications in tRNA.
Academic Article	Inhibition of DNA-PK by gefitinib causes synergism between gefitinib and cisplatin in NSCLC.
Academic Article	Interferon inducible pseudouridine modification in human mRNA by quantitative nanopore profiling.
Academic Article	[Postoperative hearing in tympanoplasty preserving the manubrium of malleus and tensor tympani muscle tendon].
Academic Article	Clinical impact of Fn-induced high expression of KIR2DL1 in CD8 T lymphocytes in oesophageal squamous cell carcinoma.
Academic Article	tRNA modification dynamics from individual organisms to metaepitranscriptomics of microbiomes.
Academic Article	Pan-cancer assessment of mutational landscape in intrinsically disordered hotspots reveals potential driver genes.
Academic Article	Long non-coding RNA ZNF674-AS1 regulates miR-23a/E-cadherin axis to suppress the migration and invasion of non-small cell lung cancer cells.
Academic Article	Profiling Selective Packaging of Host RNA and Viral RNA Modification in SARS-CoV-2 Viral Preparations.
Academic Article	The Role of the P1 Latency in Auditory and Speech Performance Evaluation in Cochlear Implanted Children.
Academic Article	A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation.
Academic Article	Analysis of queuosine and 2-thio tRNA modifications by high throughput sequencing.
Academic Article	Age-related endoplasmic reticulum stress represses testosterone synthesis via attenuation of the circadian clock in Leydig cells.
Academic Article	Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution.
Academic Article	Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications.
Academic Article	tRNA abundance, modification and fragmentation in nasopharyngeal swabs as biomarkers for COVID-19 severity.
Academic Article	Epitranscriptome profiling of spleen mRNA m6A methylation reveals pathways of host responses to malaria parasite infection.
Academic Article	Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation.
Academic Article	Structure-informed microbial population genetics elucidate selective pressures that shape protein evolution.
Academic Article	[Surgical issues and managements in cochlear reimplantation in 32 children].
Academic Article	Characteristics of the Northern Hemisphere cold regions changes from 1901 to 2019.
Concept	Protein Domains
Concept	Proteasome Inhibitors
Concept	Molecular Docking Simulation
Concept	Intrinsically Disordered Proteins
Concept	Protein Aggregates
Grant	Discovering the epigenetics of RNA modifications
Grant	Studies of RNA modifications on the genomic scale
Grant	Kinetic/Thermodynamic/Structural Studies of RNA Folding
Grant	Recognition and mechanism of N6-methyl adenosine modifications
Grant	FOLDING AND CATALYSIS OF THE RIBOZYME FROM RNASE P
Grant	Mis-translation as a new mechanism of stress response in biology
Grant	Defining the role of pseudouridine modifications in HIV biology
Grant	N6-methyladenosine and the biology of HIV
Grant	Kinetic/Thermodynamic/Structural studies of RNA folding
Grant	Mis-translation as a new mechanism of stress response in biology
Academic Article	Efficacy and Safety of Direct Oral Anticoagulants Compared With Heparin for Preventing Thromboembolism in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis.
Academic Article	Microbial community structure dynamics of invasive bullfrog with meningitis-like infectious disease.
Academic Article	Spectral separation degree method for Vis-NIR spectroscopic discriminant analysis of milk powder adulteration.
Academic Article	Probiotics improve symptoms of patients with COVID-19 through gut-lung axis: a systematic review and meta-analysis.
Academic Article	BPTF Drives Gastric Cancer Resistance to EGFR Inhibitor by Epigenetically Regulating the C-MYC/PLCG1/Perk Axis.
Academic Article	Design, construction, and functional characterization of a tRNA neochromosome in yeast.
Academic Article	Lumen-apposing metal stents versus traditional self-expanding metal stents for endoscopic ultrasound-guided drainage of pancreatic fluid collections: a systematic review and meta-analysis.
Academic Article	Simultaneous nanopore profiling of mRNA m6A and pseudouridine reveals translation coordination.
Academic Article	Impaired sensitivity to thyroid hormones is associated with albuminuria in the euthyroid population: results from NHANES.

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