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Concept Adrenal Cortex Neoplasms
Concept Alcoholism
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Concept Arcuate Nucleus of Hypothalamus
Concept Adenylyl Cyclases
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Concept Fatty Liver, Alcoholic
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Concept Mice
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Concept Thyrotrophs
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Concept Saccharomyces cerevisiae
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Concept Severity of Illness Index
Concept Thiazolidinediones
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Concept Temperature
Concept Blotting, Western
Concept Down-Regulation
Concept Logistic Models
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Concept Thiolester Hydrolases
Concept Thyroid Neoplasms
Concept Thyrotropin-Releasing Hormone
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Concept Absorptiometry, Photon
Concept Hyperandrogenism
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Concept Receptors, Adrenergic, beta-1
Concept Polymerase Chain Reaction
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Concept STAT5 Transcription Factor
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Concept Cyclic AMP-Dependent Protein Kinase Type II
Concept AMP-Activated Protein Kinases
Concept Insulin Receptor Substrate Proteins
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Concept Endoplasmic Reticulum-Associated Degradation
Concept Kaempferols
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Concept Alzheimer Disease
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Concept Blood Chemical Analysis
Concept Cell Survival
Concept Brain Ischemia
Concept Chickens
Concept Chromatin
Concept Cimetidine
Concept Cloning, Molecular
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Concept Dietary Fats
Concept Disease Models, Animal
Concept Doxorubicin
Concept Fluorescent Dyes
Concept Follow-Up Studies
Concept Genotype
Concept Gestational Age
Concept Glucose
Concept Heart Rate
Concept Heterozygote
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Concept Hypothalamus
Concept Hypothalamus, Middle
Concept Kinetics
Concept Longitudinal Studies
Concept Microscopy, Fluorescence
Concept Norepinephrine
Concept Predictive Value of Tests
Concept Propylthiouracil
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Concept Proteinuria
Concept Pulmonary Fibrosis
Concept Receptors, Adrenergic, beta
Concept Recombinant Fusion Proteins
Concept Respiration, Artificial
Concept Retrospective Studies
Concept Spermatozoa
Concept Gastric Bypass
Concept Transcriptional Activation
Concept Gene Expression Regulation, Neoplastic
Concept Hospital Mortality
Concept Cyclic AMP-Dependent Protein Kinases
Concept Hindlimb Suspension
Concept Genetic Predisposition to Disease
Concept Polymorphism, Single Nucleotide
Concept Receptors, Adrenergic, beta-3
Concept Integrin alphaVbeta3
Concept Epigenesis, Genetic
Concept p38 Mitogen-Activated Protein Kinases
Concept Sarcoplasmic Reticulum Calcium-Transporting ATPases
Concept Muscle Strength
Concept Ubiquitination
Academic Article Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Academic Article Development of compensatory thermogenesis in response to overfeeding in hypothyroid rats.
Academic Article Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage.
Academic Article Hypothyroidism and hypertension: fact or myth? - Authors' reply.
Academic Article Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.
Academic Article Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors.
Academic Article Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
Academic Article Adaptive activation of thyroid hormone and energy expenditure.
Academic Article [Thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (reverse T3) conversion in human leukocyte suspensions. Study in hyper and hypothyroidism states].
Academic Article Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.
Academic Article Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging.
Academic Article Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.
Academic Article Inactivation of the adrenergic receptor ß2 disrupts glucose homeostasis in mice.
Academic Article Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.
Academic Article Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism: A Systematic Review and Meta-Analysis.
Academic Article Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.
Academic Article Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation.
Academic Article Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
Academic Article The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Academic Article Deiodinases: implications of the local control of thyroid hormone action.
Academic Article Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles.
Academic Article Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.
Academic Article Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations.
Academic Article Thyroid hormone-related regulation of gene expression in human fatty liver.
Academic Article Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.
Academic Article Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.
Academic Article Hypothyroidism.
Academic Article Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic ß-cells and disrupts glucose homeostasis.
Academic Article Pathophysiological relevance of deiodinase polymorphism.
Academic Article Does Sex Bias Play a Role for Dissatisfied Patients With Hypothyroidism?
Academic Article The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.
Academic Article Coupling between Nutrient Availability and Thyroid Hormone Activation.
Academic Article Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue.
Academic Article Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis.
Academic Article Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.
Academic Article An inside job.
Academic Article Extrathyroidal conversion of thyroxine to 3,5,3'-triiodothyronine in cold-acclimated thyroxine-maintained thyroidectomized rats.
Academic Article Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.
Academic Article Conversion of thyroxine (T4) to T3 and rT3 in human leucocyte suspension: its application to clinical investigation.
Academic Article The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
Academic Article Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.
Academic Article Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats.
Academic Article The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion.
Academic Article Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.
Academic Article Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton.
Academic Article Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques.
Academic Article Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis.
Academic Article Minireview: cracking the metabolic code for thyroid hormone signaling.
Academic Article The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
Academic Article Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences.
Academic Article ß(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice.
Academic Article Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus.
Academic Article Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization.
Academic Article Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.
Academic Article Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold.
Academic Article Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
Academic Article Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats.
Academic Article Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.
Academic Article Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells.
Academic Article Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
Academic Article Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice.
Academic Article Cracking the code for thyroid hormone signaling.
Academic Article Amiodarone and thyroid physiology, pathophysiology, diagnosis and management.
Academic Article Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes.
Academic Article Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.
Academic Article Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.
Academic Article Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.
Academic Article 3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity.
Academic Article The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats.
Academic Article Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Academic Article Paradigms of Dynamic Control of Thyroid Hormone Signaling.
Academic Article Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Academic Article Urgent need for further research in subclinical hypothyroidism.
Academic Article The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy.
Academic Article Sustained Release T3 Therapy: Animal Models and Translational Applications.
Academic Article Patient Context and Thyrotropin Levels Are Important When Considering Treatment of Subclinical Hypothyroidism.
Academic Article Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation.
Academic Article Levothyroxine treatment and cholesterol in hypothyroidism.
Academic Article We All Know We Need Them, We Hope They Are Coming, But When?
Academic Article Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism.
Academic Article Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms.
Academic Article Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?
Academic Article Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism.
Academic Article Challenges in Developing Recommendations Based on Low-Quality Evidence in Thyroid Guidelines.
Academic Article Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice.
Academic Article Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling.
Academic Article Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Academic Article Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism.
Academic Article Accelerating functional gene discovery in osteoarthritis.
Academic Article Deiodinases and the Metabolic Code for Thyroid Hormone Action.
Academic Article Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Academic Article Letter to the Editor from Idrees and Bianco: "Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis".
Academic Article Sociodemographic Disparities in the Treatment of Hypothyroidism: NHANES 2007-2012.
Academic Article Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites.
Academic Article Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Academic Article Neonatal thyroxine activation modifies epigenetic programming of the liver.
Academic Article Publisher Correction: Accelerating functional gene discovery in osteoarthritis.
Academic Article Thyroid Hormone Levels During Hospital Admission Inform Disease Severity and Mortality in COVID-19 Patients.
Academic Article Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans.
Academic Article Deiodinase-3 is a thyrostat to regulate podocyte homeostasis.
Academic Article Response to Letter to the Editor From Bonnema et al: "Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine + Liothyronine in Hypothyroidism".
Academic Article Brain Fog in Hypothyroidism: Understanding the Patient's Perspective.
Academic Article Primary hypothyroidism and quality of life.
Academic Article Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
Academic Article Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse.
Academic Article The relevance of T3 in the management of hypothyroidism.
Academic Article Suboptimal Thyroid Hormone Replacement Is Associated With Worse Hospital Outcomes.
Academic Article Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase.
Academic Article Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism.
Academic Article Multisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams.
Academic Article T3 levels and thyroid hormone signaling.
Academic Article Enhancing the Patient Voice: Quality of Life, Satisfaction, and Preference During Treatment of Hypothyroidism.
Academic Article Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients.
Academic Article Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice.
Concept Ataxin-3
Concept Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Concept Gene Editing
Concept Binge Drinking
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Concept CRISPR-Cas Systems
Grant Thyroid-adrenergic synergism and adaptive thermogenesis
Grant Selenodeiodinase processing by the proteasome system
Grant Selenodeidinase Processing by the Proteasome System
Academic Article Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain.
Academic Article Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?
Academic Article Demographic, Healthcare Access, and Dietary Factors Associated With Thyroid Hormone Treatments for Hypothyroidism.
Academic Article Levothyroxine Treatment Adequacy and Formulation Changes in Patients with Hypothyroidism: A Retrospective Study of Real-World Data from the United States.
Academic Article The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease.
Academic Article The Effects of Patient Characteristics on the Management of Subclinical Hypothyroidism: A Survey of Faculty and Trainees.
Academic Article Emerging Therapies in Hypothyroidism.
Academic Article Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism.
Academic Article Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids.
Academic Article A Cross-Sectional Analysis of Cardiovascular and Bone Health Care Utilization During Treatment With Thyroid Hormone.
Academic Article Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism.
Academic Article The Relationship Between Work Relative Value Unit Awareness and Work Relative Value Unit Accumulation Among Physicians.
Academic Article Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
Academic Article Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment.
Academic Article Thyroid hormone homeostasis in levothyroxine-treated patients: Findings from ELSA-Brasil.
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