Item Type | Name |
Concept
|
Acute Disease
|
Concept
|
Adenine
|
Concept
|
Actins
|
Concept
|
Aorta, Thoracic
|
Concept
|
Aged, 80 and over
|
Concept
|
Aldosterone
|
Concept
|
Atropine Derivatives
|
Concept
|
Arteriovenous Malformations
|
Concept
|
Acetylcholine
|
Concept
|
Adaptation, Physiological
|
Concept
|
Aerobiosis
|
Concept
|
Calcimycin
|
Concept
|
Cyclic AMP
|
Concept
|
Berberine
|
Concept
|
Aged
|
Concept
|
Alanine
|
Concept
|
Biphenyl Compounds
|
Concept
|
Blood Flow Velocity
|
Concept
|
Blood Platelets
|
Concept
|
Bone Marrow Cells
|
Concept
|
Amino Acid Sequence
|
Concept
|
Adenosine Triphosphate
|
Concept
|
Administration, Oral
|
Concept
|
Boston
|
Concept
|
Apolipoproteins E
|
Concept
|
Hypoxia, Brain
|
Concept
|
Androstadienes
|
Concept
|
Angina Pectoris
|
Concept
|
Anti-Inflammatory Agents, Non-Steroidal
|
Concept
|
Aorta
|
Concept
|
Calmodulin
|
Concept
|
Aminoquinolines
|
Concept
|
Antihypertensive Agents
|
Concept
|
Antioxidants
|
Concept
|
Analysis of Variance
|
Concept
|
Anions
|
Concept
|
Arginine
|
Concept
|
Anti-Inflammatory Agents
|
Concept
|
B-Lymphocytes
|
Concept
|
Base Sequence
|
Concept
|
Cell Differentiation
|
Concept
|
Cell Movement
|
Concept
|
Cell Nucleus
|
Concept
|
Cerebral Infarction
|
Concept
|
Cerebrovascular Circulation
|
Concept
|
Aspirin
|
Concept
|
Atrial Fibrillation
|
Concept
|
Calcitriol
|
Concept
|
Binding Sites
|
Concept
|
Biological Transport
|
Concept
|
Basilar Artery
|
Concept
|
Bleomycin
|
Concept
|
Calcinosis
|
Concept
|
Brachial Artery
|
Concept
|
Brain
|
Concept
|
Brain Chemistry
|
Concept
|
Emergency Service, Hospital
|
Concept
|
Capillary Permeability
|
Concept
|
Cardiology
|
Concept
|
Carotid Arteries
|
Concept
|
Cattle
|
Concept
|
Cell Division
|
Concept
|
Ischemic Attack, Transient
|
Concept
|
Botulinum Toxins
|
Concept
|
Bronchoalveolar Lavage Fluid
|
Concept
|
Cholesterol, Dietary
|
Concept
|
Capillaries
|
Concept
|
Cardiomyopathy, Dilated
|
Concept
|
Cell Cycle
|
Concept
|
Combined Modality Therapy
|
Concept
|
Chemotaxis
|
Concept
|
Chicago
|
Concept
|
Blood Gas Analysis
|
Concept
|
Blood-Brain Barrier
|
Concept
|
Bradykinin
|
Concept
|
Collateral Circulation
|
Concept
|
C-Reactive Protein
|
Concept
|
Cholesterol
|
Concept
|
Circadian Rhythm
|
Concept
|
Citrulline
|
Concept
|
Clotrimazole
|
Concept
|
Coronary Artery Disease
|
Concept
|
Diabetes Mellitus, Type 1
|
Concept
|
Huntington Disease
|
Concept
|
Densitometry
|
Concept
|
Imidazoles
|
Concept
|
Cost Control
|
Concept
|
Cytochrome P-450 Enzyme System
|
Concept
|
Cytoskeleton
|
Concept
|
Cerebral Hemorrhage
|
Concept
|
Dogs
|
Concept
|
Echocardiography
|
Concept
|
Electrophoresis, Polyacrylamide Gel
|
Concept
|
Chromatography
|
Concept
|
Chromones
|
Concept
|
Exons
|
Concept
|
Corpus Striatum
|
Concept
|
Depression
|
Concept
|
Cross-Sectional Studies
|
Concept
|
Disease Susceptibility
|
Concept
|
Dipyridamole
|
Concept
|
Metalloporphyrins
|
Concept
|
Indomethacin
|
Concept
|
Introns
|
Concept
|
Enzyme Activation
|
Concept
|
Mice, Inbred C3H
|
Concept
|
Molsidomine
|
Concept
|
Ergonovine
|
Concept
|
Myosin-Light-Chain Kinase
|
Concept
|
Gingiva
|
Concept
|
KB Cells
|
Concept
|
Guanosine Triphosphate
|
Concept
|
Obesity
|
Concept
|
Cyclic GMP
|
Concept
|
Hydrogen Peroxide
|
Concept
|
Hydroxyeicosatetraenoic Acids
|
Concept
|
Eosinophils
|
Concept
|
Hydroxymethylglutaryl CoA Reductases
|
Concept
|
Fibrinolysis
|
Concept
|
Flow Cytometry
|
Concept
|
Interleukin-1
|
Concept
|
Mesenteric Arteries
|
Concept
|
Metformin
|
Concept
|
Leukocytes
|
Concept
|
Immunoglobulin E
|
Concept
|
Mice, Inbred Strains
|
Concept
|
Virulence Factors, Bordetella
|
Concept
|
Phenylephrine
|
Concept
|
Mice, Transgenic
|
Concept
|
Platelet-Derived Growth Factor
|
Concept
|
Potassium Chloride
|
Concept
|
Illinois
|
Concept
|
Immunohistochemistry
|
Concept
|
Glycolysis
|
Concept
|
Oxadiazoles
|
Concept
|
Mice, Inbred BALB C
|
Concept
|
Mice, Inbred C57BL
|
Concept
|
Middle Aged
|
Concept
|
Receptors, Angiotensin
|
Concept
|
Cricetinae
|
Concept
|
Neural Tube Defects
|
Concept
|
Lipopolysaccharides
|
Concept
|
Cholesterol, HDL
|
Concept
|
Salicylates
|
Concept
|
Patient Discharge
|
Concept
|
Sodium Salicylate
|
Concept
|
Phosphorylation
|
Concept
|
Nitrites
|
Concept
|
Nitroprusside
|
Concept
|
Oxygen
|
Concept
|
Tissue Plasminogen Activator
|
Concept
|
Platelet Aggregation
|
Concept
|
Protein Binding
|
Concept
|
Protein Conformation
|
Concept
|
Protein Processing, Post-Translational
|
Concept
|
Homocysteine
|
Concept
|
Immunoglobulin G
|
Concept
|
Regional Blood Flow
|
Concept
|
Heart Septal Defects, Ventricular
|
Concept
|
Rabbits
|
Concept
|
Quinolines
|
Concept
|
Quinoxalines
|
Concept
|
Cohort Studies
|
Concept
|
Receptors, Adrenergic, alpha
|
Concept
|
Smoking
|
Concept
|
RNA Processing, Post-Transcriptional
|
Concept
|
Mass Spectrometry
|
Concept
|
Swine
|
Concept
|
Thrombin
|
Concept
|
Humans
|
Concept
|
Body Mass Index
|
Concept
|
Bone Marrow Transplantation
|
Concept
|
Ticlopidine
|
Concept
|
Transcription, Genetic
|
Concept
|
Protein Biosynthesis
|
Concept
|
Tetrazoles
|
Concept
|
Superoxides
|
Concept
|
Triiodothyronine
|
Concept
|
Stroke Volume
|
Concept
|
Tumor Necrosis Factor-alpha
|
Concept
|
Plasminogen Activator Inhibitor 1
|
Concept
|
Drug Design
|
Concept
|
Ultraviolet Rays
|
Concept
|
Biomarkers
|
Concept
|
Cholesterol, LDL
|
Concept
|
Caspases
|
Concept
|
Peptide Elongation Factor 1
|
Concept
|
RGS Proteins
|
Concept
|
rho GTP-Binding Proteins
|
Concept
|
rhoB GTP-Binding Protein
|
Concept
|
Tyrosine
|
Concept
|
rac1 GTP-Binding Protein
|
Concept
|
Raloxifene Hydrochloride
|
Concept
|
Veratrine
|
Concept
|
Up-Regulation
|
Concept
|
Mice, Inbred ICR
|
Concept
|
Carotid Stenosis
|
Concept
|
Mitochondria
|
Concept
|
Mitochondria, Muscle
|
Concept
|
Second Messenger Systems
|
Concept
|
CD4-Positive T-Lymphocytes
|
Concept
|
Radionuclide Ventriculography
|
Concept
|
Interleukin-8
|
Concept
|
Proto-Oncogene Proteins c-fos
|
Concept
|
Cytochalasin D
|
Concept
|
Eicosanoids
|
Concept
|
Rats, Sprague-Dawley
|
Concept
|
Rats, Wistar
|
Concept
|
Case-Control Studies
|
Concept
|
Protein Structure, Tertiary
|
Concept
|
Motor Activity
|
Concept
|
Myosins
|
Concept
|
Angiopoietin-2
|
Concept
|
Neurites
|
Concept
|
Bronchial Hyperreactivity
|
Concept
|
Hypertrophy, Left Ventricular
|
Concept
|
Arachidonic Acid
|
Concept
|
Apoptosis
|
Concept
|
Annexin A5
|
Concept
|
Mice, Knockout
|
Concept
|
Receptors, AMPA
|
Concept
|
Cell Proliferation
|
Concept
|
GTP-Binding Protein alpha Subunits, Gs
|
Concept
|
omega-N-Methylarginine
|
Concept
|
ras Proteins
|
Concept
|
Interferon-Stimulated Gene Factor 3
|
Concept
|
Th2 Cells
|
Concept
|
Infarction, Middle Cerebral Artery
|
Concept
|
GTP-Binding Protein alpha Subunits, Gi-Go
|
Concept
|
Bone Morphogenetic Protein Receptors, Type II
|
Concept
|
Caspase 3
|
Concept
|
Cross-Over Studies
|
Concept
|
Ankle Brachial Index
|
Concept
|
Intracranial Embolism
|
Concept
|
Matrix Metalloproteinase 2
|
Concept
|
Cyclic GMP-Dependent Protein Kinases
|
Concept
|
Pertussis Toxin
|
Concept
|
Receptor, Angiotensin, Type 2
|
Concept
|
Atherosclerosis
|
Concept
|
Vascular Endothelial Growth Factors
|
Concept
|
Catenins
|
Concept
|
Sterol Regulatory Element Binding Protein 2
|
Concept
|
Angiotensin II Type 1 Receptor Blockers
|
Concept
|
COS Cells
|
Concept
|
Transcription Factor AP-1
|
Concept
|
3' Untranslated Regions
|
Concept
|
Hydroxymethylglutaryl-CoA Reductase Inhibitors
|
Concept
|
ras GTPase-Activating Proteins
|
Concept
|
rhoA GTP-Binding Protein
|
Concept
|
rac GTP-Binding Proteins
|
Concept
|
Platelet Endothelial Cell Adhesion Molecule-1
|
Concept
|
Cationic Amino Acid Transporter 1
|
Concept
|
Goblet Cells
|
Concept
|
Hemangioma, Cavernous, Central Nervous System
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p21
|
Concept
|
Popliteal Artery
|
Concept
|
Precipitin Tests
|
Concept
|
Promoter Regions, Genetic
|
Concept
|
Mice
|
Concept
|
Early Growth Response Protein 1
|
Concept
|
Pulmonary Artery
|
Concept
|
Pyrroles
|
Concept
|
Rats, Inbred Strains
|
Concept
|
Acute Coronary Syndrome
|
Concept
|
Glycogen Synthase Kinase 3
|
Concept
|
Prenylation
|
Concept
|
Structure-Activity Relationship
|
Concept
|
Interferon Regulatory Factors
|
Concept
|
Rats
|
Concept
|
Nitric Oxide Synthase Type II
|
Concept
|
Period Circadian Proteins
|
Concept
|
Adaptor Proteins, Signal Transducing
|
Concept
|
Chemokine CXCL10
|
Concept
|
Blotting, Western
|
Concept
|
Down-Regulation
|
Concept
|
Multivariate Analysis
|
Concept
|
Cyclins
|
Concept
|
Angiotensin II Type 2 Receptor Blockers
|
Concept
|
Tibial Arteries
|
Concept
|
Phosphatidylinositol 3-Kinase
|
Concept
|
8,11,14-Eicosatrienoic Acid
|
Concept
|
Blotting, Northern
|
Concept
|
Molecular Structure
|
Concept
|
Platelet Activation
|
Concept
|
Cell Hypoxia
|
Concept
|
ATP-Binding Cassette Transporters
|
Concept
|
Coronary Angiography
|
Concept
|
Cyclin-Dependent Kinases
|
Concept
|
Protein Prenylation
|
Concept
|
GTP-Binding Proteins
|
Concept
|
NG-Nitroarginine Methyl Ester
|
Concept
|
Myeloid Differentiation Factor 88
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
Concept
|
Intracranial Hemorrhages
|
Concept
|
Interleukin-17
|
Concept
|
Stroke
|
Concept
|
cdc42 GTP-Binding Protein
|
Concept
|
Interleukin-13
|
Concept
|
Blood Vessel Prosthesis Implantation
|
Concept
|
Carotid Artery Injuries
|
Concept
|
Monomeric GTP-Binding Proteins
|
Concept
|
GTPase-Activating Proteins
|
Concept
|
MAP Kinase Signaling System
|
Concept
|
Extracellular Signal-Regulated MAP Kinases
|
Concept
|
gamma Catenin
|
Concept
|
Basic Helix-Loop-Helix Transcription Factors
|
Concept
|
Keratin-14
|
Concept
|
Angiotensin Receptor Antagonists
|
Concept
|
RNA, Small Interfering
|
Concept
|
Vascular Endothelial Growth Factor A
|
Concept
|
GTP-Binding Protein alpha Subunits, Gq-G11
|
Concept
|
Cell Line, Tumor
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p27
|
Concept
|
Nuclear Receptor Coactivator 3
|
Concept
|
Anticholesteremic Agents
|
Concept
|
Hypolipidemic Agents
|
Concept
|
Arteriosclerosis
|
Concept
|
Brain Neoplasms
|
Concept
|
Calcium
|
Concept
|
Calcium Channel Blockers
|
Concept
|
Cerebral Arteries
|
Concept
|
Brain Ischemia
|
Concept
|
Coronary Vessels
|
Concept
|
Desmosomes
|
Concept
|
Femoral Artery
|
Concept
|
Follow-Up Studies
|
Concept
|
Kinetics
|
Concept
|
Longitudinal Studies
|
Concept
|
Mice, Mutant Strains
|
Concept
|
Monocytes
|
Concept
|
Prospective Studies
|
Concept
|
Retrospective Studies
|
Concept
|
Sphingosine
|
Concept
|
T-Lymphocytes
|
Concept
|
Violence
|
Concept
|
Signal Transduction
|
Concept
|
Interleukin-5
|
Concept
|
Tumor Suppressor Protein p53
|
Concept
|
Cyclic AMP-Dependent Protein Kinases
|
Concept
|
Porins
|
Concept
|
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
|
Concept
|
Nitroarginine
|
Concept
|
Chemokines, CXC
|
Concept
|
Losartan
|
Concept
|
Proto-Oncogene Proteins c-sis
|
Concept
|
RNA Stability
|
Concept
|
Adherens Junctions
|
Concept
|
Adaptor Proteins, Vesicular Transport
|
Concept
|
MicroRNAs
|
Concept
|
ADP Ribose Transferases
|
Concept
|
Vascular Endothelial Growth Factor Receptor-1
|
Concept
|
Estrogen Receptor alpha
|
Concept
|
Proto-Oncogene Proteins c-akt
|
Concept
|
Smad Proteins
|
Concept
|
Young Adult
|
Concept
|
HLA-DR alpha-Chains
|
Academic Article
|
Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase.
|
Academic Article
|
Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene.
|
Academic Article
|
Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.
|
Academic Article
|
Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?
|
Academic Article
|
Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells.
|
Academic Article
|
Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
|
Academic Article
|
Increased Rho kinase activity in a Taiwanese population with metabolic syndrome.
|
Academic Article
|
Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.
|
Academic Article
|
Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.
|
Academic Article
|
Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
|
Academic Article
|
A method for measuring Rho kinase activity in tissues and cells.
|
Academic Article
|
Essential role of endothelial Notch1 in angiogenesis.
|
Academic Article
|
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.
|
Academic Article
|
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
|
Academic Article
|
Smooth muscle Notch1 mediates neointimal formation after vascular injury.
|
Academic Article
|
Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction.
|
Academic Article
|
Squalene synthase inhibitor lapaquistat acetate: could anything be better than statins?
|
Academic Article
|
Increased Rho kinase activity in congestive heart failure.
|
Academic Article
|
Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.
|
Academic Article
|
Statins inhibit Rho kinase activity in patients with atherosclerosis.
|
Academic Article
|
Statins and cardiovascular diseases: from cholesterol lowering to pleiotropy.
|
Academic Article
|
Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.
|
Academic Article
|
Role of Rho kinase isoforms in murine allergic airway responses.
|
Academic Article
|
Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.
|
Academic Article
|
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
|
Academic Article
|
Deficiency of ROCK1 in bone marrow-derived cells protects against atherosclerosis in LDLR-/- mice.
|
Academic Article
|
Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness.
|
Academic Article
|
Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen.
|
Academic Article
|
Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation.
|
Academic Article
|
Rho kinase: an important mediator of atherosclerosis and vascular disease.
|
Academic Article
|
Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice.
|
Academic Article
|
Rho-associated kinase activity, endothelial function, and cardiovascular risk factors.
|
Academic Article
|
Induction of endothelial-leukocyte interaction by interferon-gamma requires coactivation of nuclear factor-kappaB.
|
Academic Article
|
Inhibition of vascular smooth muscle cell proliferation by sodium salicylate mediated by upregulation of p21(Waf1) and p27(Kip1).
|
Academic Article
|
Rapid effects of statins: from prophylaxis to therapy for ischemic stroke.
|
Academic Article
|
Non-nuclear actions of estrogen: new targets for prevention and treatment of cardiovascular disease.
|
Academic Article
|
Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase.
|
Academic Article
|
Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol.
|
Academic Article
|
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.
|
Academic Article
|
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.
|
Academic Article
|
A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
|
Academic Article
|
Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.
|
Academic Article
|
Endothelium-dependent effects of statins.
|
Academic Article
|
Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease.
|
Academic Article
|
Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
|
Academic Article
|
Nonnuclear actions of estrogen.
|
Academic Article
|
Isoprenoid metabolism and the pleiotropic effects of statins.
|
Academic Article
|
Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation.
|
Academic Article
|
Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases.
|
Academic Article
|
Does it matter whether or not a lipid-lowering agent inhibits Rho kinase?
|
Academic Article
|
Mitohormesis: another pleiotropic effect of statins?
|
Academic Article
|
gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice.
|
Academic Article
|
ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.
|
Academic Article
|
Pleiotropic effects of statins.
|
Academic Article
|
FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1.
|
Academic Article
|
Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction.
|
Academic Article
|
Translational therapeutics of dipyridamole.
|
Academic Article
|
Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event.
|
Academic Article
|
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
|
Academic Article
|
Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.
|
Academic Article
|
Linking endothelial dysfunction with endothelial cell activation.
|
Academic Article
|
The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor.
|
Academic Article
|
Functional interaction of endothelial nitric oxide synthase with a voltage-dependent anion channel.
|
Academic Article
|
The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis.
|
Academic Article
|
Rac1 is a critical mediator of endothelium-derived neurotrophic activity.
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Academic Article
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Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.
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Academic Article
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Isoprenoids as mediators of the biological effects of statins.
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Academic Article
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Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells.
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Academic Article
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Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.
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Academic Article
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VEGF increases retinal vascular ICAM-1 expression in vivo.
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Academic Article
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Safety and efficacy of statins in Asians.
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Academic Article
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Inhibition of major histocompatibility complex class II gene transcription by nitric oxide and antioxidants.
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Academic Article
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Statins and ischemic stroke.
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Academic Article
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Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
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Academic Article
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Evidence of pleiotropy by statins: leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors.
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Academic Article
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Rho-kinase inhibition acutely augments blood flow in focal cerebral ischemia via endothelial mechanisms.
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Academic Article
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1alpha,25-dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase.
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Academic Article
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3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1).
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Academic Article
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Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinase.
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Academic Article
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A functional role of I kappa B-epsilon in endothelial cell activation.
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Academic Article
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Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.
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Academic Article
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Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells.
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Academic Article
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Statins: potent vascular anti-inflammatory agents.
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Academic Article
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Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
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Academic Article
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Cross-coupling between the oestrogen receptor and phosphoinositide 3-kinase.
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Academic Article
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Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.
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Academic Article
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ROCKs as therapeutic targets in cardiovascular diseases.
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Academic Article
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Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment.
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Academic Article
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NF-?B and innate immunity in ischemic stroke.
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Academic Article
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Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.
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Academic Article
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Nontranscriptional actions of the glucocorticoid receptor.
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Academic Article
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Acute myocardial infarction after ergonovine administration for uterine bleeding.
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Academic Article
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Rho GTPases, statins, and nitric oxide.
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Academic Article
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Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen.
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Academic Article
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Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis.
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Academic Article
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Neuroprotection mediated by changes in the endothelial actin cytoskeleton.
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Academic Article
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Clinical implications for statin pleiotropy.
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Academic Article
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ROCKs as immunomodulators of stroke.
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Academic Article
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Pleiotropic effects of statin therapy: molecular mechanisms and clinical results.
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Academic Article
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Physiological role of ROCKs in the cardiovascular system.
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Academic Article
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Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury.
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Academic Article
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Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
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Academic Article
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A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome.
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Academic Article
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Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.
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Academic Article
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Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.
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Academic Article
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Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2.
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Academic Article
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Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha.
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Academic Article
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Requirement of Rac1 in the development of cardiac hypertrophy.
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Academic Article
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ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
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Academic Article
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Potential serum biomarkers in the pathophysiological processes of stroke.
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Academic Article
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Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
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Academic Article
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Linking Notch signaling to ischemic stroke.
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Academic Article
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[New findings on the action of HMG-CoA-reductase inhibitors].
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Academic Article
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Modulation of bradykinin receptor ligand binding affinity and its coupled G-proteins by nitric oxide.
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Academic Article
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Additive effects of statin and dipyridamole on cerebral blood flow and stroke protection.
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Academic Article
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Simvastatin decreases IL-6 and IL-8 production in epithelial cells.
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Academic Article
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Statin therapy: having the good without the bad.
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Academic Article
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Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.
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Academic Article
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Statins and myocardial hypertrophy.
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Academic Article
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Salicylates and vascular smooth muscle cell proliferation: molecular mechanisms for cell cycle arrest.
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Academic Article
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Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway.
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Academic Article
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Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants.
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Academic Article
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Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase.
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Academic Article
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Novel aspects of the roles of Rac1 GTPase in the cardiovascular system.
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Academic Article
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Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.
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Academic Article
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Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1.
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Academic Article
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Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein.
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Academic Article
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FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
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Academic Article
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Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
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Academic Article
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Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
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Academic Article
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Rapid nongenomic actions of thyroid hormone.
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Academic Article
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Rho kinase (ROCK) inhibitors.
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Academic Article
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NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy.
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Academic Article
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Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection.
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Academic Article
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Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
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Academic Article
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Fine-tuning the angiogenic response to vascular endothelial growth factor.
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Academic Article
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Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.
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Academic Article
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Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia.
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Academic Article
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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase.
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Academic Article
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Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein.
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Academic Article
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MnTBAP stimulates angiogenic functions in endothelial cells through mitofusin-1.
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Academic Article
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Effect of torcetrapib in patients at high risk for coronary events.
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Academic Article
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ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice.
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Academic Article
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Statin therapy is associated with improved patency of autogenous infrainguinal bypass grafts.
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Academic Article
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Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study.
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Academic Article
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Critical role of endothelial Notch1 signaling in postnatal angiogenesis.
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Academic Article
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Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis.
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Academic Article
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Distribution of sphingosine kinase activity and mRNA in rodent brain.
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Academic Article
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HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events.
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Academic Article
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Increased leukocyte ROCK activity in patients after acute ischemic stroke.
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Academic Article
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Drug Insight: statins and stroke.
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Academic Article
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Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.
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Academic Article
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11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.
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Academic Article
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Relative Lack of Culprit and Obstructive Coronary Lesions in Patients With Acute Ischemic Stroke and Elevated Cardiac Troponin.
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Academic Article
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Role of statin pleiotropism in acute coronary syndromes and stroke.
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Academic Article
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Genetically elevated C-reactive protein and ischemic vascular disease.
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Academic Article
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Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma.
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Academic Article
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Rho Kinases and Cardiac Remodeling.
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Academic Article
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Two functional polymorphisms of ROCK2 enhance arterial stiffening through inhibiting its activity and expression.
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Academic Article
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Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
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Academic Article
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Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical Bleeding.
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Academic Article
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Fingolimod provides long-term protection in rodent models of cerebral ischemia.
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Academic Article
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RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
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Academic Article
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Activation of guanine nucleotide-binding proteins and induction of endothelial tissue-type plasminogen activator gene transcription by alcohol.
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Academic Article
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Targeting Rho in cardiovascular disease.
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Academic Article
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Lipid management with statins. The lower the better?
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Academic Article
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Targeting eNOS for stroke protection.
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Academic Article
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Nuclear run-on assay to study gene transcription in vascular cells.
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Academic Article
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Specific receptor-guanine nucleotide binding protein interaction mediates the release of endothelium-derived relaxing factor.
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Academic Article
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[Regulation of endothelial NO production by Rho GTPase].
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Academic Article
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Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1.
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Academic Article
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Direct vascular effects of HMG-CoA reductase inhibitors.
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Academic Article
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Pleiotropic Effects of Statins on the Cardiovascular System.
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Academic Article
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Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms.
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Academic Article
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Preservation of NO production by statins in the treatment of heart failure.
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Academic Article
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Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptor.
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Academic Article
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Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets.
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Academic Article
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Beyond lipid lowering: the role of statins in vascular protection.
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Academic Article
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Statin therapy for cardiac hypertrophy and heart failure.
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Academic Article
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Cardiology Consultation in the Emergency Department Reduces Re-hospitalizations for Low-Socioeconomic Patients with Acute Decompensated Heart Failure.
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Academic Article
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Tumor necrosis factor-a levels and non-surgical bleeding in continuous-flow left ventricular assist devices.
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Academic Article
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Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.
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Academic Article
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Inhibition of MHC II gene transcription by nitric oxide and antioxidants.
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Academic Article
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Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase.
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Academic Article
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Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase.
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Academic Article
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ROCK as a therapeutic target for ischemic stroke.
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Academic Article
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Simvastatin preserves cardiac function in genetically determined cardiomyopathy.
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Academic Article
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The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke to Atrial Fibrillation and Ventricular Tachyarrhythmia.
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Academic Article
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Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
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Academic Article
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Eplerenone improves endothelial function and arterial stiffness and inhibits Rho-associated kinase activity in patients with idiopathic hyperaldosteronism: a pilot study.
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Academic Article
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Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.
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Academic Article
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Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
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Academic Article
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Is statin discontinuation an option in patients who have had a stroke?
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Academic Article
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Role of angiotensin II receptor subtypes in porcine basilar artery: functional, radioligand binding, and cell culture studies.
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Academic Article
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Dynamic regulation of endothelial NOS mediated by competitive interaction with alpha-actinin-4 and calmodulin.
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Academic Article
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Association of Rising Violent Crime With Blood Pressure and Cardiovascular Risk: Longitudinal Evidence From Chicago, 2014-2016.
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Academic Article
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A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
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Academic Article
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Community Health Workers Reduce Rehospitalizations and Emergency Department Visits for Low-Socioeconomic Urban Patients With Heart Failure.
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Academic Article
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Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis.
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Academic Article
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Long-term statin use and psychological well-being.
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Academic Article
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Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia.
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Academic Article
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SALAD-BAAR: A numerical risk score for hospital admission or emergency department presentation in ambulatory patients with cardiovascular disease.
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Academic Article
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Emerging views of statin pleiotropy and cholesterol lowering.
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Academic Article
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Berberine suppresses MEK/ERK-dependent Egr-1 signaling pathway and inhibits vascular smooth muscle cell regrowth after in vitro mechanical injury.
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Academic Article
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Challenging Statin Pleiotropy: Preeclampsia.
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Academic Article
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Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms.
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Concept
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Fingolimod Hydrochloride
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Concept
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Liver X Receptors
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Concept
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Glycogen Synthase Kinase 3 beta
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Concept
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KRIT1 Protein
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Concept
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Percutaneous Coronary Intervention
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Concept
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ATP Binding Cassette Transporter 1
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Grant
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Endothelial Akt in Vascular Injury
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Grant
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ROCK and Obesity
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Academic Article
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Understanding the molecular mechanisms of statin pleiotropic effects.
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Academic Article
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A Novel HIF-2a/ARNT Signaling Pathway Protects Against Microvascular Dysfunction and heart failure After Myocardial Infarction.
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Academic Article
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Role of Rho-Associated Kinase in the Pathophysiology of Cerebral Cavernous Malformations.
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