| Item Type | Name |
|
Concept
|
Adenocarcinoma
|
|
Concept
|
Antigens, Neoplasm
|
|
Concept
|
Antibiotics, Antineoplastic
|
|
Concept
|
Alkylation
|
|
Concept
|
Audiometry, Pure-Tone
|
|
Concept
|
Breast Neoplasms
|
|
Concept
|
Alkylating Agents
|
|
Concept
|
Amino Acid Sequence
|
|
Concept
|
Antigens, Differentiation
|
|
Concept
|
Antineoplastic Agents
|
|
Concept
|
Carcinoma, Squamous Cell
|
|
Concept
|
Animals
|
|
Concept
|
Antimetabolites, Antineoplastic
|
|
Concept
|
Antineoplastic Combined Chemotherapy Protocols
|
|
Concept
|
Carcinoma
|
|
Concept
|
Arabinonucleosides
|
|
Concept
|
B-Lymphocytes
|
|
Concept
|
Base Sequence
|
|
Concept
|
Carmustine
|
|
Concept
|
Deuterium
|
|
Concept
|
Bayes Theorem
|
|
Concept
|
Azacitidine
|
|
Concept
|
Carcinoma, Renal Cell
|
|
Concept
|
Astrocytoma
|
|
Concept
|
Binding Sites
|
|
Concept
|
Bilirubin
|
|
Concept
|
Biopsy
|
|
Concept
|
Cattle
|
|
Concept
|
Cell Division
|
|
Concept
|
Colon
|
|
Concept
|
Cell Transformation, Viral
|
|
Concept
|
Cerebellar Neoplasms
|
|
Concept
|
Carcinogens
|
|
Concept
|
Floxuridine
|
|
Concept
|
Colonic Neoplasms
|
|
Concept
|
Cell Transformation, Neoplastic
|
|
Concept
|
Chicago
|
|
Concept
|
Codon
|
|
Concept
|
Genital Neoplasms, Female
|
|
Concept
|
Leucovorin
|
|
Concept
|
Glutathione Peroxidase
|
|
Concept
|
Glutathione Transferase
|
|
Concept
|
Cricetulus
|
|
Concept
|
Colony-Forming Units Assay
|
|
Concept
|
Injections, Intra-Arterial
|
|
Concept
|
Injections, Intraperitoneal
|
|
Concept
|
Drug Hypersensitivity
|
|
Concept
|
Cyclophosphamide
|
|
Concept
|
Daunorubicin
|
|
Concept
|
Glycerol
|
|
Concept
|
Kidney Neoplasms
|
|
Concept
|
Enzyme Inhibitors
|
|
Concept
|
Leukemia
|
|
Concept
|
Etoposide
|
|
Concept
|
Cytarabine
|
|
Concept
|
Disease Susceptibility
|
|
Concept
|
Double-Blind Method
|
|
Concept
|
Infant, Newborn
|
|
Concept
|
Introns
|
|
Concept
|
Methyltransferases
|
|
Concept
|
Microtubule-Associated Proteins
|
|
Concept
|
Deoxyadenosines
|
|
Concept
|
Deoxyguanosine
|
|
Concept
|
Glioma
|
|
Concept
|
Glioblastoma
|
|
Concept
|
Feasibility Studies
|
|
Concept
|
Hearing Loss, Conductive
|
|
Concept
|
Obesity
|
|
Concept
|
Oncogenes
|
|
Concept
|
Dose-Response Relationship, Drug
|
|
Concept
|
Drug Labeling
|
|
Concept
|
Liver Neoplasms
|
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
|
Concept
|
Herpesvirus 4, Human
|
|
Concept
|
Hydroxamic Acids
|
|
Concept
|
Flow Cytometry
|
|
Concept
|
Infusions, Intravenous
|
|
Concept
|
Genetics, Medical
|
|
Concept
|
Leukocytes, Mononuclear
|
|
Concept
|
Hearing Loss, Noise-Induced
|
|
Concept
|
Membrane Glycoproteins
|
|
Concept
|
Methylnitrosourea
|
|
Concept
|
Carcinoma, Hepatocellular
|
|
Concept
|
Mice, Inbred Strains
|
|
Concept
|
Microfilament Proteins
|
|
Concept
|
Models, Molecular
|
|
Concept
|
Pharmacogenetics
|
|
Concept
|
Phosphoramide Mustards
|
|
Concept
|
Pilot Projects
|
|
Concept
|
Macaca mulatta
|
|
Concept
|
Mammals
|
|
Concept
|
Naphthoquinones
|
|
Concept
|
Methylnitronitrosoguanidine
|
|
Concept
|
Mice, Transgenic
|
|
Concept
|
Models, Genetic
|
|
Concept
|
Models, Theoretical
|
|
Concept
|
Neutropenia
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Mutagens
|
|
Concept
|
Necrosis
|
|
Concept
|
Mice, Inbred BALB C
|
|
Concept
|
Mice, Inbred C57BL
|
|
Concept
|
Mice, Nude
|
|
Concept
|
Microsomes, Liver
|
|
Concept
|
Random Allocation
|
|
Concept
|
Mycosis Fungoides
|
|
Concept
|
Cricetinae
|
|
Concept
|
Hot Temperature
|
|
Concept
|
Rhabdomyosarcoma
|
|
Concept
|
Interleukin-3
|
|
Concept
|
Isotope Labeling
|
|
Concept
|
Nigeria
|
|
Concept
|
Kidney Tubules
|
|
Concept
|
Leukemia L1210
|
|
Concept
|
Nucleic Acid Conformation
|
|
Concept
|
Ovarian Neoplasms
|
|
Concept
|
Ovary
|
|
Concept
|
Lomustine
|
|
Concept
|
Luciferases
|
|
Concept
|
Lung Neoplasms
|
|
Concept
|
Sensation Disorders
|
|
Concept
|
Ornithine Decarboxylase
|
|
Concept
|
Medulloblastoma
|
|
Concept
|
Melphalan
|
|
Concept
|
Patient Acceptance of Health Care
|
|
Concept
|
Sezary Syndrome
|
|
Concept
|
Mesylates
|
|
Concept
|
Neoplasms, Germ Cell and Embryonal
|
|
Concept
|
Magnetic Resonance Spectroscopy
|
|
Concept
|
Poly T
|
|
Concept
|
Population Surveillance
|
|
Concept
|
Prednisone
|
|
Concept
|
Preoperative Care
|
|
Concept
|
Prostatic Neoplasms
|
|
Concept
|
Protein Conformation
|
|
Concept
|
Protein-Arginine N-Methyltransferases
|
|
Concept
|
Protein Synthesis Inhibitors
|
|
Concept
|
Idoxuridine
|
|
Concept
|
Rats, Inbred F344
|
|
Concept
|
Recurrence
|
|
Concept
|
Regression Analysis
|
|
Concept
|
Head and Neck Neoplasms
|
|
Concept
|
Registries
|
|
Concept
|
Procaine
|
|
Concept
|
Risk Factors
|
|
Concept
|
Quality of Life
|
|
Concept
|
Cohort Studies
|
|
Concept
|
Genes, ras
|
|
Concept
|
Rats, Nude
|
|
Concept
|
Speech Perception
|
|
Concept
|
Risk
|
|
Concept
|
Semustine
|
|
Concept
|
Sensitivity and Specificity
|
|
Concept
|
Swine
|
|
Concept
|
Tachycardia, Supraventricular
|
|
Concept
|
Thymidine
|
|
Concept
|
Humans
|
|
Concept
|
Hypercholesterolemia
|
|
Concept
|
Body Mass Index
|
|
Concept
|
Cluster Analysis
|
|
Concept
|
Linear Models
|
|
Concept
|
Tretinoin
|
|
Concept
|
Testicular Neoplasms
|
|
Concept
|
Injections, Intravenous
|
|
Concept
|
United States
|
|
Concept
|
United States Food and Drug Administration
|
|
Concept
|
Tumor Stem Cell Assay
|
|
Concept
|
Ketoconazole
|
|
Concept
|
Germ-Line Mutation
|
|
Concept
|
Leiomyosarcoma
|
|
Concept
|
Cholesterol, LDL
|
|
Concept
|
Rhabdomyosarcoma, Alveolar
|
|
Concept
|
Oncogene Proteins, Fusion
|
|
Concept
|
Randomized Controlled Trials as Topic
|
|
Concept
|
Risk Assessment
|
|
Concept
|
Cell Culture Techniques
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Caspases
|
|
Concept
|
Transforming Growth Factor beta
|
|
Concept
|
Central Nervous System Neoplasms
|
|
Concept
|
Electrophoretic Mobility Shift Assay
|
|
Concept
|
Myosin Type II
|
|
Concept
|
Southwestern United States
|
|
Concept
|
DNA Modification Methylases
|
|
Concept
|
Prevalence
|
|
Concept
|
Mutagenesis
|
|
Concept
|
Metabolic Clearance Rate
|
|
Concept
|
Activin Receptors, Type I
|
|
Concept
|
Antigens, CD
|
|
Concept
|
Antimutagenic Agents
|
|
Concept
|
Lymph Nodes
|
|
Concept
|
Leukemia, Myeloid, Acute
|
|
Concept
|
CD4-Positive T-Lymphocytes
|
|
Concept
|
Rats, Sprague-Dawley
|
|
Concept
|
Nervous System Neoplasms
|
|
Concept
|
Case-Control Studies
|
|
Concept
|
Galectin 3
|
|
Concept
|
Melanoma
|
|
Concept
|
Methionine
|
|
Concept
|
Methylation
|
|
Concept
|
Treatment Outcome
|
|
Concept
|
Neoplasm Metastasis
|
|
Concept
|
Neoplasm Recurrence, Local
|
|
Concept
|
Neoplasms, Experimental
|
|
Concept
|
Oligodeoxyribonucleotides
|
|
Concept
|
Consensus Sequence
|
|
Concept
|
Neurites
|
|
Concept
|
Interferon-alpha
|
|
Concept
|
Annexin A5
|
|
Concept
|
Gene Deletion
|
|
Concept
|
Sequence Deletion
|
|
Concept
|
Gliosarcoma
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Genes, X-Linked
|
|
Concept
|
Antigens, CD34
|
|
Concept
|
Neoplasms, Squamous Cell
|
|
Concept
|
Disease Progression
|
|
Concept
|
Immunomagnetic Separation
|
|
Concept
|
Hepatocyte Nuclear Factor 1-alpha
|
|
Concept
|
Simvastatin
|
|
Concept
|
Antineoplastic Agents, Alkylating
|
|
Concept
|
Caspase 3
|
|
Concept
|
Base Pair Mismatch
|
|
Concept
|
Neurofibromin 1
|
|
Concept
|
Amino Acid Transport Systems, Basic
|
|
Concept
|
Multidrug Resistance-Associated Proteins
|
|
Concept
|
CpG Islands
|
|
Concept
|
Myosin Heavy Chains
|
|
Concept
|
Fluorescent Antibody Technique, Indirect
|
|
Concept
|
Paresthesia
|
|
Concept
|
Cladribine
|
|
Concept
|
Protein Structure, Secondary
|
|
Concept
|
Self Report
|
|
Concept
|
Primary Cell Culture
|
|
Concept
|
Green Fluorescent Proteins
|
|
Concept
|
Geographic Information Systems
|
|
Concept
|
Cortactin
|
|
Concept
|
Area Under Curve
|
|
Concept
|
Proto-Oncogene Proteins B-raf
|
|
Concept
|
5' Untranslated Regions
|
|
Concept
|
Caspase 1
|
|
Concept
|
Anthracyclines
|
|
Concept
|
Oligonucleotide Array Sequence Analysis
|
|
Concept
|
3' Untranslated Regions
|
|
Concept
|
Stem Cell Factor
|
|
Concept
|
Caspase 12
|
|
Concept
|
Glucuronides
|
|
Concept
|
Loss of Heterozygosity
|
|
Concept
|
Databases, Genetic
|
|
Concept
|
Physicians
|
|
Concept
|
Platinum
|
|
Concept
|
Polydeoxyribonucleotides
|
|
Concept
|
Polyethylene Glycols
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Mice
|
|
Concept
|
Rectum
|
|
Concept
|
Rats, Inbred Strains
|
|
Concept
|
Sarcoma
|
|
Concept
|
Severity of Illness Index
|
|
Concept
|
Research Design
|
|
Concept
|
RNA, Messenger
|
|
Concept
|
Suppression, Genetic
|
|
Concept
|
Thionucleosides
|
|
Concept
|
Thrombopoietin
|
|
Concept
|
Tinnitus
|
|
Concept
|
Gastrointestinal Stromal Tumors
|
|
Concept
|
Rats
|
|
Concept
|
ADP-ribosyl Cyclase 1
|
|
Concept
|
Real-Time Polymerase Chain Reaction
|
|
Concept
|
Skin Neoplasms
|
|
Concept
|
Stereotaxic Techniques
|
|
Concept
|
Streptozocin
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Colorectal Neoplasms
|
|
Concept
|
Models, Statistical
|
|
Concept
|
Glutathione S-Transferase pi
|
|
Concept
|
MutS Homolog 2 Protein
|
|
Concept
|
Life Tables
|
|
Concept
|
Multivariate Analysis
|
|
Concept
|
Survival Analysis
|
|
Concept
|
DNA Copy Number Variations
|
|
Concept
|
Tetradecanoylphorbol Acetate
|
|
Concept
|
Thymidylate Synthase
|
|
Concept
|
Electronic Health Records
|
|
Concept
|
Drug Monitoring
|
|
Concept
|
Reproducibility of Results
|
|
Concept
|
Treatment Failure
|
|
Concept
|
Interleukin-11
|
|
Concept
|
Gene Expression Regulation, Leukemic
|
|
Concept
|
Survival Rate
|
|
Concept
|
Rhabdomyosarcoma, Embryonal
|
|
Concept
|
Odds Ratio
|
|
Concept
|
Polymerase Chain Reaction
|
|
Concept
|
Granulocyte Colony-Stimulating Factor
|
|
Concept
|
ATP-Binding Cassette Transporters
|
|
Concept
|
Patient Selection
|
|
Concept
|
Receptor, ErbB-2
|
|
Concept
|
Lymphoma, Large B-Cell, Diffuse
|
|
Concept
|
Proliferating Cell Nuclear Antigen
|
|
Concept
|
Cyclin-Dependent Kinases
|
|
Concept
|
DNA Methylation
|
|
Concept
|
Microsatellite Instability
|
|
Concept
|
Precursor Cell Lymphoblastic Leukemia-Lymphoma
|
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
|
Concept
|
Xenograft Model Antitumor Assays
|
|
Concept
|
Gene Knockdown Techniques
|
|
Concept
|
O(6)-Methylguanine-DNA Methyltransferase
|
|
Concept
|
Cation Transport Proteins
|
|
Concept
|
Inhibitory Concentration 50
|
|
Concept
|
Hearing Loss
|
|
Concept
|
Organic Anion Transporters
|
|
Concept
|
Tubulin Modulators
|
|
Concept
|
Genome-Wide Association Study
|
|
Concept
|
Precision Medicine
|
|
Concept
|
RNA, Small Interfering
|
|
Concept
|
Molecular Sequence Annotation
|
|
Concept
|
CDC2-CDC28 Kinases
|
|
Concept
|
Hand-Foot Syndrome
|
|
Concept
|
Cytochrome P-450 CYP3A
|
|
Concept
|
Proto-Oncogene Proteins c-bcr
|
|
Concept
|
Myeloid-Lymphoid Leukemia Protein
|
|
Concept
|
Kaplan-Meier Estimate
|
|
Concept
|
Healthcare Disparities
|
|
Concept
|
Induced Pluripotent Stem Cells
|
|
Concept
|
Topoisomerase II Inhibitors
|
|
Concept
|
Anti-Bacterial Agents
|
|
Concept
|
Antibodies
|
|
Concept
|
Antineoplastic Agents, Phytogenic
|
|
Concept
|
Auditory Threshold
|
|
Concept
|
Brain Neoplasms
|
|
Concept
|
Calcium
|
|
Concept
|
Cardiovascular Agents
|
|
Concept
|
Chlorambucil
|
|
Concept
|
Chromosomes, Human
|
|
Concept
|
Chromosomes, Human, Pair 16
|
|
Concept
|
Clinical Trials as Topic
|
|
Concept
|
Colistin
|
|
Concept
|
Deoxycytidine
|
|
Concept
|
Disease Models, Animal
|
|
Concept
|
DNA, Single-Stranded
|
|
Concept
|
Doxorubicin
|
|
Concept
|
Drug Screening Assays, Antitumor
|
|
Concept
|
Electrochemistry
|
|
Concept
|
Ethylnitrosourea
|
|
Concept
|
Follow-Up Studies
|
|
Concept
|
Genetic Testing
|
|
Concept
|
Health Status
|
|
Concept
|
Ifosfamide
|
|
Concept
|
Leukemia P388
|
|
Concept
|
Lymphocyte Activation
|
|
Concept
|
Lymphocytes
|
|
Concept
|
Mice, Mutant Strains
|
|
Concept
|
Microscopy, Fluorescence
|
|
Concept
|
Plicamycin
|
|
Concept
|
Models, Biological
|
|
Concept
|
Models, Neurological
|
|
Concept
|
Monocytes
|
|
Concept
|
Neuroblastoma
|
|
Concept
|
Platelet Aggregation Inhibitors
|
|
Concept
|
Predictive Value of Tests
|
|
Concept
|
Procarbazine
|
|
Concept
|
Prospective Studies
|
|
Concept
|
Retrospective Studies
|
|
Concept
|
Ribonucleoside Diphosphate Reductase
|
|
Concept
|
Speech
|
|
Concept
|
Thymus Gland
|
|
Concept
|
Translocation, Genetic
|
|
Concept
|
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
|
|
Concept
|
5'-Nucleotidase
|
|
Concept
|
Immunophenotyping
|
|
Concept
|
Granulocyte-Macrophage Colony-Stimulating Factor
|
|
Concept
|
Databases, Factual
|
|
Concept
|
Anticarcinogenic Agents
|
|
Concept
|
Mitomycin
|
|
Concept
|
Ribonucleoproteins, Small Nuclear
|
|
Concept
|
DNA Primers
|
|
Concept
|
Receptors, Transforming Growth Factor beta
|
|
Concept
|
Electroporation
|
|
Concept
|
Disease-Free Survival
|
|
Concept
|
Hyaluronan Receptors
|
|
Concept
|
Genetic Predisposition to Disease
|
|
Concept
|
Polymorphism, Single Nucleotide
|
|
Concept
|
Membrane Transport Proteins
|
|
Concept
|
Databases, Nucleic Acid
|
|
Concept
|
Adaptor Proteins, Vesicular Transport
|
|
Concept
|
MicroRNAs
|
|
Concept
|
Semaphorins
|
|
Concept
|
Protein Array Analysis
|
|
Concept
|
Chromosomes, Human, X
|
|
Concept
|
Protein Kinase Inhibitors
|
|
Concept
|
Cyclin-Dependent Kinase 2
|
|
Concept
|
Caspase 9
|
|
Concept
|
Glypicans
|
|
Academic Article
|
5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: a clinical and pharmacologic analysis.
|
|
Academic Article
|
Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea.
|
|
Academic Article
|
Peripheral blood mononuclear cell dihydropyrimidine dehydrogenase activity in volunteers with and without diabetes mellitus.
|
|
Academic Article
|
Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo.
|
|
Academic Article
|
O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
|
|
Academic Article
|
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
|
|
Academic Article
|
Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
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Academic Article
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Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer.
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Academic Article
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Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity.
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Academic Article
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A phase II trial of oral temozolomide in patients with metastatic renal cell cancer.
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Academic Article
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Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
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Academic Article
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Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
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Academic Article
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Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene.
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Academic Article
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Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells.
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Academic Article
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Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
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Academic Article
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Effect of population and gender on chemotherapeutic agent-induced cytotoxicity.
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Academic Article
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Genetic variants contributing to daunorubicin-induced cytotoxicity.
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Academic Article
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Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity.
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Academic Article
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Identification of genetic variants and gene expression relationships associated with pharmacogenes in humans.
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Academic Article
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Expression and alternative splicing of folate pathway genes in HapMap lymphoblastoid cell lines.
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Academic Article
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Etoposide pathway.
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Academic Article
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Impact of the 1000 genomes project on the next wave of pharmacogenomic discovery.
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Academic Article
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Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.
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Academic Article
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Gene set enrichment analyses revealed differences in gene expression patterns between males and females.
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Academic Article
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Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci.
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Academic Article
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Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach.
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Academic Article
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Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.
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Academic Article
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Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
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Academic Article
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A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter.
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Academic Article
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Functional consequences of PRPF39 on distant genes and cisplatin sensitivity.
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Academic Article
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Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.
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Academic Article
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Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation.
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Academic Article
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Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Copy number polymorphisms and anticancer pharmacogenomics.
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Academic Article
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Human liver oxidative metabolism of O6-benzylguanine.
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Academic Article
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Sequential therapy with dacarbazine and carmustine: a phase I study.
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Academic Article
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Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
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Academic Article
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A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.
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Academic Article
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Mapping genes that contribute to daunorubicin-induced cytotoxicity.
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Academic Article
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Creating and evaluating genetic tests predictive of drug response.
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Academic Article
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Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel.
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Academic Article
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Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.
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Academic Article
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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
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Academic Article
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Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
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Academic Article
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Activity of temozolomide in the treatment of central nervous system tumor xenografts.
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Academic Article
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Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase.
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Academic Article
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Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
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Academic Article
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Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
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Academic Article
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A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
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Academic Article
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1,3- vs 1,5-intramolecular alkylation reactions in isophosphoramide and phosphoramide mustards.
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Academic Article
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Genetic variants in cytosolic 5'-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia.
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Academic Article
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Multicenter phase II trial of temozolomide in mycosis fungoides/sezary syndrome: correlation with O6-methylguanine-DNA methyltransferase and mismatch repair proteins.
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Academic Article
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Lymphoblastoid cell lines in pharmacogenomics: how applicable are they to clinical outcomes?
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Academic Article
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Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
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Academic Article
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Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
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Academic Article
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Mechanisms of resistance to the toxicity of cyclophosphamide.
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Academic Article
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Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.
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Academic Article
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Linking the genetic architecture of cytosine modifications with human complex traits.
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Academic Article
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Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.
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Academic Article
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Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.
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